CRC seminar February 23


John Nolan, CEO and Head
Steno Diabetes Center A/S

Time & place

Thursday February 23 at 4 p.m. in Lecture Hall, CRC, entr 72, SUS Malmö.


Type 2 diabetes in young people: pathophysiology and response to exercise and diet intervention


Early onset type 2 diabetes is increasing in prevalence, in parallel with pandemic obesity. The early onset phenotype has been described in the US and Japan, and in ethnic populations with a higher prevalence of type 2 diabetes. However, the most important trend is a rapid escalation of early presentation in developing countries, particularly in Asia. Clinically, type 2 diabetes in youth is associated with obesity and extreme insulin resistance. We have reported that these patients respond poorly to areobic exercise intervention. Plasma metabolic profiles of these patients show a distinct "signature" when compared with patients with later onset diabetes or age-matched young subjects who are obese but with normal glucose tolerance.

This presentation will outline phenotypic features of early onset type 2 diabetes, as well as changes within skeletal muscle that may contribute to poor responses to exercise intervention.


Professor John Nolan was appointed CEO of the Steno Diabetes Center, Denmark, in January 2011. He was consultant in endocrinology and metabolism and head of the Metabolic Reserach Unit at St James´s Hospital Dublin from 1996-2010. John Nolan is a Visiting Professor of Medicine at Trinity College Dublin.

John Nolan is a graduate of UCD, and completed fellowship training at the University of California, San Diego. His research focuses on the pathophysiology of Type 2 diabetes. John is the lead investigator of a new EU commission funded consortium that will study the mechanisms underlying the prevention of type 2 diabetes. John has been a member of the Executive of the European Association for the Study of Diabetes (EASD) and Chair of Postgraduate Education fo the EASD, from 2006-2010.
John Nolan is the recipient of many awards and honours, and is a Fellow of both the Royal Colleges of Physician of Ireland and Edinburgh.
John Nolan is an honorary Fellow of Trinity College Dublin.

Last updated: February 6, 2012
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