CRC seminar January 26

Speaker

Francis Finucane, Galway University Hospital, Ireland

Time & place

Thursday January 26th in Lecture Hall, CRC, entr 72, SUS Malmö

Title

What Can we Learn from an Exercise Intervention in a British Cohort?

Introduction

Francis Finucane qualified from RCSI in 1998 and completed physician trainign in Beaumont Hospital, obtaining the MRCPI in 2001. He continued clinical training in endocrinology, diabetes mellitus and general internal medicine in Dublin, including a period of clinicla research at the Metabolic Research Unit in St. James´ Hospital. There, Francis conducted detailed metabolic assessments of young people with obesity, insulin resistance and type 2 diabetes and was awarded an MD from the University of Dublin (TCD) in 2008 for his work.

Francis Finucane completed specialist training in endocrinology and internal medicine the same year. In order to explore further the mechanistic basis for the association between insulin resistance and adiposity, he undertook a four year period of post-doctoral research at the Institute of Metabolic Science in Cambridge, funded by travel grants from Irish training bodies and a Career Development Fellowship from the Medical Research Council. Building on his wirk in Dublin, he contucted a formal assessment of the effects of aerobic exercise in older people and different factors modulating the response to exercise.
Francis published the first study to show that exercise reduces liver fat content in humans.

Francis Finucane led the writing group on a major international collaboration describing a novel genetic polymorphism associated with reduced body fat but increased diabetes and cardiovascular risk.

Since returning to Ireland in 2010, Dr. Finucane has led the development of clinical services for people wigh severe obesity and related metabolic disorders from the West of Ireland.

Some selection of publications:

1: Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, …Loos RJ. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011 Jun 26;43(8):753-60. doi: 10.1038/ng.866. PubMed PMID: 21706003.

2: Leelarathna L, Ward C, Davenport K, Donald S, Housden A, Finucane FM, Evans M.

Reduced insulin requirements during participation in the DAFNE (dose adjustment for normal eating) structured education programme. Diabetes Res Clin Pract. 2011 May;92(2):e34-6. Epub 2011 Jan 26. PubMed PMID: 21269721.

3: Griffin SJ, Simmons RK, Williams KM, Prevost AT, Hardeman W, Grant J, Whittle F, Boase S, Hobbis I, Brage S, Westgate K, Fanshawe T, Sutton S, Wareham NJ, Kinmonth AL; ADDITION-Plus study team. Protocol for the ADDITION-Plus study: a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care. BMC Public Health. 2011 Apr 4;11:211. PubMed PMID: 21463520; PubMed Central PMCID: PMC3076276.

4: Huang-Doran I, Bicknell LS, Finucane FM, Rocha N, Porter KM, Tung YC, Szekeres

F, Krook A, Nolan JJ, O'Driscoll M, Bober M, O'Rahilly S, Jackson AP, Semple RK;

Majewski Osteodysplastic Primordial Dwarfism Study Group. Genetic defects in human pericentrin are associated with severe insulin resistance and diabetes.
Diabetes. 2011 Mar;60(3):925-35. Epub 2011 Jan 26. PubMed PMID: 21270239; PubMed Central PMCID: PMC3046854.

5: Hatunic M, Finucane FM, Norris S, Pacini G, Nolan JJ. Glucose metabolism after normalization of markers of iron overload by venesection in subjects with hereditary hemochromatosis. Metabolism. 2010 Dec;59(12):1811-5. Epub 2010 Aug 1.  PubMed PMID: 20673928.