Åke Lernmark

Contact Information

Prof. Åke Lernmark PhD

Address

Lund University/CRC, Malmö
Dep. of Clinical Sciences
Diabetes & Celiac Disease Unit
University Hospital MAS
SE-20502 Malmö, Sweden

Phone

+46 40 39 19 01

Fax

+46 40 39 19 19

E-mail

ake.lernmark@remove-this-part.med.lu.se

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Head of Unit

Åke Lernmark PhD, Professor

Immunogenetics of Type 1 Diabetes

The HLA DQ locus is the major genetic risk factor for both type 1 diabetes and celiac disease.  Both diseases are also linked to several non−HLA candidate genes, which may modify risk. Several but different etiological factors in the environment have also been implicated in the disease risk for type 1 diabetes and celiac disease. The pathogenesis of type 1 diabetes is strongly associated with the appearance of autoantibodies against GAD65, IA−2, ZnT8 and insulin, alone or in combination. Our laboratory cloned human islet GAD65 and developed a novel assay now in worldwide use to detect these autoantibodies and other autoantibodies such as those against tissue transglutaminase that predict celiac disease.

Ongoing Projects

DiPiS: Diabetes Prediction in Skåne

CiPiS: Celiac Disease Prediction in Skåne

TEDDY: The Environmental Determinants of Diabetes in the Young

BDD: Better Diabetes Diagnosis

GDA: Global Diabetes Alliance

DIAPREPP: DIAbetes type 1 Prediction, Early Pathogenesis and Prevention

DIAPREV-IT: DIAbetes PREVention – Immune Tolerance

TrialNet

READ-ON: REtinopathy After Diabetes ONset

DOHK: Diabetes and Cardiovascular Risk factors (Diabetes Och Hjärta-Kärl)

EFSD

RSKC

SUMMIT

Last updated: November 30, 2009
Website contact: LUDC webteam

LUDC, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00