Type 2 diabetes is considered as a paradigm for a multifactorial polygenic disease where variants in a number of genetic factors interact with environment to manifest the disease.
Type 2 diabetes affects 10-15% of the worlds population and the figures are predicted to double within the next 15 years. These conditions are assumed to develop from the interaction between genetic predisposition and an affluent environment. The aim of our research is to identify genetic factors contributing to these conditions but also to dissect the interaction between genes and environment. To accomplish this different strategies have been adopted including whole genome association studies (WGAS), candidate gene screening, expression profiling of human islets, muscle and fat as well as studies of chromatin modifications including DNA methylation etc
A prerequisite for these studies is access to one of the largest and best characterised type 2 diabetes family collections in the world, i.e. the Botnia Study. (Groop et al. Diabetes 45: 1585-1593, 1996).
Last updated: June 16, 2010
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