Contact information

Addresse

CRC, entr 72, building 60, floor 12
Scania University Hospital Malmö
SE-205 02  Malmö, Sweden

Phone

Fax

+46 40 391222

E-mail

Yang.De_Marinis@remove-this-part.med.lu.se

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Yang de Marinis

Associate researcher

Current project

Osteopontin (OPN) is a glycoprotein synthesized and secreted by different cell types from various tissues including bone, kidney, smooth muscle and immune organs. OPN promotes cell survival, migration and adhesion by binding to integrins present on the cell surface. Overexpression of OPN has been associated with several physiological and pathological conditions in response to inflammation and other immunologic disorders. Previous studies have revealed that OPN is up-regulated in the serum of type 1 diabetic patients, in diabetic vascular walls and kidneys. The aim of our investigation is to get a better understanding on the protective effect of OPN in islets, as well as the regulation of OPN expression in normal and diabetic islets in association with different regulatory hormones, e.g. GIP and GLP-1.

Last updated: February 24, 2010
Website contact: LUDC webteam

LUDC, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00