Contact

Lund University
Dept of Clinical Sciences Malmö
CRC, Jan Waldenströms gata 35, SUS Malmö
SE-205 02  Malmö, Sweden

E-mail

Tereza.Planck@med.lu.se

Theresa Planck

MD, PhD

Graves´Disease and Graves´ophthalmopathy

Background

Graves´ disease is the most common type of hyperthyroidism. It is a complex disease that develops as a result of the interplay between genetic, endogeneous and environmental factors. Graves´ ophthalmopathy occurs in approximately one third of the patients with Graves´ disease. It is a chronic, disfiguring eye disease with major negatie impact of the health related quality of life. The pathogenesis of Graves´ ophthalmopathy is not entirely understood. One important isk factor is smoking. The current treatment options for Graves´ ophthalmopathy are limited and associated with side effects.

Aim of the project

To contribute to the understanding of the etiology of Graves´ disease and Graves´ ophthalmopathy and define target genes and pathways for possible therapeutic intervention.

Ongoing studies

  1. Genetic backsround of Graves´ disease and Graves´ ophthalmopathy
  2. Common genetic background of Graves´ disease and other autoimmune diseases such as rheumatoid arthritis and type 1 diabetes
  3. Studies of associations of certain risk factors (smoking, D-vitamin status) with Graves´ disease
  4. Expression profiling of intraorbital adipose tissue in patients with Graves´ ophthalmopathy and healthy controls with special regard to smoking status
  5. Identification of a marker for the development of Graves´ ophthalmopathy in patients with Graves´ disease
  6. In vitro studies of the effect of smoking in Graves´ ophthalmopathy and possible therapeutic interventions

Last updated: May 19, 2014
Website contact: LUDC webteam

LUDC, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00