Contact

Address

Department of Clinical Scieces Malmö, Islet Cell Exocytosis,
CRC, Entr 72, building 81, Level 11, University Hospital Malmö
SE-205 02  Malmö, Sweden

Phone

+46 40 391169

Fax

+46 40 391222

E-mail

Ines.Mollet AT med.lu.se

Ines G. Mollet

Associate Researcher

Current project

Transcriptional regulatory networks and control of homeostasis

Current project focus is on transcriptional regulation of microRNA networks in relation to diabetes and the role of microRNAs in the control of pancreatic islet stimulus-secretion coupling, including profiling of downstream microRNA target networks.

Academic degree

PhD in Biomedical Sciences from Faculty of Medicine, University of Lisbon, Portugal, with Prof. M. Carmo-Fonseca. Thesis – Genome Wide Mining of alternative Splicing In Metazoan Model Organisms.

Work in progress

Event Posters

Mollet I.G., Malm H., Anna Wendt, Orho-Melander M., Eliasson L. Calcium-Calmodulin Transcriptional Activator, a new player in the regulation of microRNAs and insulin secretion. Lund University Diabetes Centre, Dept Clinical Sciences Malmö, Lund University, Malmö, Sweden. (Presented at: Islet Study Group – ISG - 2014, Lausanne).

Malm H.A., Mollet I.G., Esguerra J.L.S., Orho-Melander M., Eliasson L. Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells. Lund University Diabetes Centre, Dept Clinical Sciences Malmö, Lund University,Malmö, Sweden. (European Association for the Study of Diabetes – EASD - 2014, Vienna).

Vishal A Salunkhe, Olof Elvstam, Jonathan LS Esguerra, Lena Eliasson, Jenny Vikman and Anna Wendt. Glucose-stimulated insulin secretion is reduced after treatment with rosuvastatin calcium. Lund University Diabetes Centre, Dept Clinical Sciences Malmö, Lund University,Malmö, Sweden. (European Association for the Study of Diabetes - EASD - 2014, Vienna).

Vishal A. Salunkhe, Sofia A. Andersson, Jonathan L.S. Esguerra, Ines G. Mollet, Anna Wendt and Lena Eliasson. Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS-1 832/13 cells . Islet Cell Exocytosis, Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. (Presented at: European Association for the Study of Diabetes – EASD - 2013, Barcelona)

G. Hindy, I. G. Mollet, G.Rukh, U. Ericson, M. Orho-Melander. Several type 2 diabetes associated variants in WNT pathway associated genes interact with dietary fiber on type 2 diabetes incidence. Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden. (Presented at: European Association for the Study of Diabetes – EASD - 2013, Barcelona).

Latest publications

Gitte L. Christensen, Maria L. B. Jacobsen, Anna Wendt, Ines G. Mollet, Josefine Friberg, Klaus S. Frederiksen, Michael Meyer, Christine Bruun, Lena Eliasson and Nils Billestrup, Bone Morphogenetic Protein 4 inhibits insulin secretion from rodent beta cells through regulation of Calbindin1 expression and reduced voltage dependent calcium currents. Diabetologia, Feb 2015.

Salunkhe VA, Esguerra JL, Ofori JK, Mollet IG, Braun M, Stoffel M, Wendt A, Eliasson L. Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells. Acta Physiol (Oxf). 2015 Jan 28. doi: 10.1111/apha.12460. [Epub ahead of print] PubMed PMID:25627423.

Esguerra JL, Mollet IG, Salunkhe VA, Wendt A, Eliasson L. Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs. Genes (Basel). 2014 Nov 6;5(4):1018-31. doi: 10.3390/genes5041018. Review. PubMed PMID: 25383562; PubMed Central PMCID: PMC4276924.

Fadista J, Vikman P, Laakso EO, Mollet IG, Esguerra JL, Taneera J, Storm P, Osmark P, Ladenvall C, Prasad RB, Hansson KB, Finotello F, Uvebrant K, Ofori JK, Di Camillo B, Krus U, Cilio CM, Hansson O, Eliasson L, Rosengren AH, Renström E, Wollheim CB, Groop L. Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9.

Edsfeldt A, Gonçalves I, Grufman H, Nitulescu M, Dunér P, Bengtsson E, Mollet IG, Persson A, Nilsson M, Orho-Melander M, Melander O, Björkbacka H, Nilsson J. Impaired Fibrous Repair: A Possible Contributor to Atherosclerotic Plaque Vulnerability in Patients With Type II Diabetes. Arterioscler Thromb Vasc Biol. 2014 Jul 17. pii: ATVBAHA.114.303414.

Sharoyko VV, Abels M, Sun J, Nicholas LM, Mollet IG, Stamenkovic JA, Göhring I, Malmgren S, Storm P, Fadista J, Spégel P, Metodiev MD, Larsson NG, Eliasson L, Wierup N, Mulder H. Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes. Hum Mol Genet. 2014 Jun 10. pii: ddu288.

Reinbothe TM, Safi F, Axelsson AS, Mollet IG, Rosengren AH. Optogenetic control of insulin secretion in intact pancreatic islets with β-cell-specific expression of Channelrhodopsin-2. Islets, 2014; Feb 18;6.

Research Networks

ORCID: http://orcid.org/0000-0002-1422-1336

ResearchGate: https://www.researchgate.net/profile/Ines_Mollet/contributions

Svenska Läkaresällskapet (Swedish Society of Medicine): www.sls.se

European Association for the Study of Diabetes (EASD)

Last updated: March 16, 2015
Website contact: LUDC webteam

LUDC, CRC, SUS Malmö, Entrance 72, House 91:12. SE-205 02 Malmö. Telephone: +46 40 39 10 00