Publications

1.    Göhring I, Sharoyko VV, Malmgren S, Andersson LE, Spegel P, Nicholls DG,    Mulder H. Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. J Biol Chem. 2013 Dec 19. [Epub ahead of print]
2.    Kumar P, Sharoyko VV, Spégel P, Gullberg U, Mulder H, Olsson I, Ajore R. The transcriptional co-repressor myeloid translocation gene 16 inhibits glycolysis and stimulates mitochondrial respiration. PloS One 8(7):e68502, 2013
3.    Malmgren S, Spégel P, Danielsson AP, Nagorny CL, Andersson LE, Dekker Nitert M, Ridderstråle M, Mulder H*, Ling C*. Coordinate changes in histone modifications, mRNA levels and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity. J Biol Chem 288: 11973-87, 2013; * equal contribution
4.    Lindqvist A, Spégel P, Ekelund M, Mulder H, Groop L, Hedenbro J, Wierup N. Effects of ingestion routes on hormonal and metabolic profiles in gastic-bypassed humans. J Clin Endocrinol Metab 98: E856-61, 2013
5.    Spégel P, Sharoyko VV, Göhring I, Danielsson AP, Malmgren S, Nagorny CL, Andersson LE, Koeck T, Sharp GW, Straub SG, Wollheim CB, Mulder H. Time-resolved metabolomics analysis of beta-cells implicates the pentose phosphate pathway in the control of insulin release. Biochem J 450: 595-605, 2013  
6.    Spegel P, Ekholm E, Tuomi T, Groop L, Mulder H, Filipsson K. Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2). Diabetes 62:653-61, 2013
7.    Goehring I, Gerencser AA, Schmidt S, Brand MD, Mulder H, Nicholls DG. Plasma Membrane Potential Oscillations in Insulin Secreting Ins-1 832/13 Cells do not Require Glycolysis and are not Initiated by Fluctuations in Mitochondrial Bioenergetics. J Biol Chem 287: 15706-17, 2012   
8.    Stamenkovic J, Olsson AH, Nagorny CLF, Dekker-Nitert M, Malmgren S, Taneera J, Köck T, Ling C, Mulder H. Regulation of Core CLOCK genes in human islets. Metabolism 61: 978-85, 2012
9.    Danielsson A, Moritz T, Mulder H, Spégel P. Development of a Gas Chromatography/
Mass Spectrometry-based Metabolomics Protocol by means of Statistical Experimental Design. Metabolomics 8: 50-63, 2012
10.    Koeck T, Olsson AH, Dekker Nitert M, Sharoyko VV, Ladenvall C, Kotova O, Reiling E, Rönn T, Parikh H, Taneera J, Eriksson JG, Metodiev MD, Larsson NG,  Balhuizen A, Luthman H, Stančáková A, Kuusisto J, Laakso M, Poulsen P, Vaag A, Groop L, Lyssenko V, Mulder H*, Ling C* A common variant in TFB1M is associated with reduced insulin secretion and increased future risk of type 2 diabetes. Cell Metabolism 13: 80-91, 2011; * equal contribution
11.    Spégel P, Malmgren S, Sharoyko VV, Newsholme P, Koeck T, Mulder H. Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines. Biochem J, 435:277-84, 2011
12.    Krus U, Kotova O, Spégel P, Hallgard E, Sharoyko VV, Vedin A, Moritz T, Sugden MC, Köck T, Mulder H. Pyruvate Dehydrogenase Kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal β-cells. Biochem J 429:205-13, 2010
13.    Danielsson A, Moritz T, Mulder H, Spégel P. Development and Optimization of a Metabolomics Method for Analysis of Adherent Cell Cultures. Anal Biochem 404:30-9, 2010
14.    Spégel P, Danielsson A, Bacos K, Nagorny CLF, Mulder H, Filipsson K. Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism, Metabolomics 6:56-66, 2010

Last updated: January 27, 2014
Website contact: LUDC webteam

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