Contact

Address

Lund University
Dept of Clinical Sciences Malmö
CRC, entr 72, SUS Malmö
SE-205 02  Malmö, Sweden

E-mail

Fabiana.Blanco@remove-this-part.med.lu.se

Fabiana Blanco

Current position

PhD-student

Academic degree

Bachelor in Biology, Faculty of Science, Unversidad de la Rebública, 2002.

Master of Science (MSc), PEDECIBA, Universidad de la República. Thesis: "Estudio de la actividad biológica de nitrolípidos y su efecto sobrre las propiedades mecánicas de la pared arterial". Mentors: Dr. Homero Rubbo and Ricardo L. Amentano.2007.

Current research interest

Macro- and microvascular complications of diabetes: Studies on NFAT (Nuclear Factor of Acivated T-cells) as a novel target for the treatment of atherosclerosis and vascular dysfunction in diabetes.

Ongoing projects

  1. Test the impact of NFAT signaling inhibition in vivo in a type 2 diabetic model that better replicates the human pathology and develops advanced atherosclerotic plaques.
  2. Use novel non-invasive nethods to longitudinally assess diabetes-induced atherosclerosis and specifically ask whether treatment with the NFAT blocker A-285222 leads to plaque regression or limited progression of lesions or both.
  3. Test the role of NFATc2 isoform in the development of microvascular complications of diabetes.

Publications

Articles

  • Desing, synthesis and biological charcterization of novel antiatherogenic tocopherol analogs-nitric oxide donors. Gloria V. López, Carlos Batthyány, Fabiana Blanco, Horacio Botti, Andrès Trostchansky, Rafael Radi, Mercedes González, Hugo Cerecetto and Homero Rubbo. Bioorg. Med. Chem.; 13(20):5787-5796;2005.
  • Second generation of α-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical and biological characterization. Gloria V. López, Fabiana Blanco, Paola Hernández, Ana Ferreira, Oscar E. Piro, Carlos Batthyány, Mercedes Gonzàlez, Homero Rubbo and Hugo Cerecetto. Bioorg. Med. Chem.; 15:6262-6272;2007.
  • Synthesis, Isomer Characterization, and Anti-Inflammatory Properties of Nitroarachidonate. Andrès Trostchansky, José M. Souza, Ana Ferreira, Mariana Ferrari, Fabiana Blanco, Madia Trujillo, Diego Castro, Hugo Cerecetto, Paul R.S. Baker, Valerie B. O´Donnell and Homero Rubbo. Biochemistry; 46, 4645-4653; 2007.
  • 6-meethyl-nitroarachidonate: anovel asterified nitroalkene which potently inhibits platelet aggregation and exerts cGMP mediated vascular relaxation. Fabiana Blanco, Ana M. Ferreira, Gloria V. López, Lucia Bonilla, Mercedes González, Hugo Cerecetto, Andrés Trostchansky and Homero Rubbo. Free Radical Biology and Medicine. FRBM, manuscript number D-10-00311, January 2011.

Congress Communication

  • Efectos de la respiración sobre la variabilidad de la frecuencia cardiaca. Fabiana Blanco, Mª Angélica Gómez, Eduardo Migliaro. IX Meeting of Biosciences Society of Uruguay. Mldonado, Uruguay, 2000, pp86.
  • Effect of the natural flavonoid on isolated aortic rings contraction and relaxation. Fabiana Blanco, Mª Angélica Gómez, Eduardo Migliaro, XI Sccientific Forum of International Society of Latin-Americans Heart Research, Belo Horizonte, Brasil, 2001-
  • Patrones Iocomotores y eléctricosen el cortejo de Brachyhypopomus pinnicaudatus. Rossana Perrone, Fabiana Blanco, Alberto Capurro, Ana Silva y Omar Macadar. X Meeting of Biosciences Society of Uruguay. Maldonade, Uruguay, 2002, pp100.
  • Efecto del flavonoide natural quercetina sobre anillos de aorta aislada, contracción y relajación. Mª Angélica Gomez, Fabiana Blanco y Eduardo Migliaro. X meting of Biosciences Society of Uruguay. Maldonade, Uruguay, 5/2002, pp75.
  • Seasonal and differences in locomotor and electric displays in Brachyhypopomus pinnicaudatus. L. Quintana, R. Perrone, A. Silva, A. Capurro, F. Sierra, F. Blanco, O. Macadar. 32nd Annual Meeting of the Society for Neutroscience, rlando, EEUU, 2002.
  • Synthesis and Biological Characterization of novel nitric oxide donors: A Pharmacological approach for Atherogenesis. Lòpez Virginia; Blanco F.; Batthyány, C., Méndez, S.; Castro D, Möller M, Migliaro E, Denicola A, González M, CerecetoH and Rubbo H. 12th Biennal Meeting of the Society for Free Radical Research Intrnational, Bs.As, Argentina, 2004, pp68.
  • Novels Tocopherol analogs as Nitric Oxide Donors. Lopez V, Batthyány C, Blanco F, González M, Rubbo H, Cerecetto H. 2nd Brazilian Symposium on Medicinal Chemsitry. Rio de Janeiro, Brazil, 2004, pp56.
  • Characterizción biológica de dadores de NO miméticos de tocoferol. Blanco, Fabiana, LópezV, Battyhány C, Gómez M.A, Mai S, González M, Cerecetto H, Migliaro E.R., Rubbo H,. III Workshop of Young Biologist, School of Science, Montevideo, Uruguay, 2004, pp51.
  • Synthesis and Biological Properties of Nitroarachionates. Andrés Trostchansky, Diego Castro, Fabiana Blanco, José M. Souza, Gloria V. Lopez, Mercedes Gonzalez, Hugo Cerecetto and Homero Rubbo. IV Meeting of the South American group of the siciety for Free Radical Biology and Medicine. Águas de Lindoia, SP, Brazil, 2005.
  • Diseño, Sintesis y Evaluación Biológica de Liberadores de Óxido Nitrico. López V, Batthyány C, Blanco F, Botti H, Trostchansky A, González M, Rubbo H, Cerecetto H. XV National Symposium of Organic Chemsitry. Mar del Plata, Argentin, 2005, pp98.
  • Synthesis, Characterization and Anti-Inflammatory Properties of Nitroarachidonate. Andrés Trostchansky, José M Souza, Ana Ferreira, Mariana Ferrari, Madia Trujillo, Fabiana Blanco, Valerie O´Donnell and Homero Rubbo. SFRMB´s 12th Annual Meeting Free Radical Biology and Medicine, Texas, USA, 2005.
  • Activated IX Meeting of Biosciences Society of Uruguay Lavalleja, Uruguay, 2005, pp241.
  • Sintesis y propiedades biológicas de nitroaraquidonato. Trotchansky A, Castro D, Blanco F, Souza JM, López V, González M, Cerecetto H, Rubbo H. IX Meeting of Biosciences Society of Uruguay, Lavalleja, Uruguay, 2005, pp44.
  • Biological properties of nitrated derivatives of arachidonic acid. Blanco F, Trostchansky A, Castro D, López V, Migliaro ER, Cerecetto H, Rubbo H. XXXV Annual meeting of the Biochemistry and Molecular Biology society of Brazil, Águas de Lindoia, Sao Paulo, Brazil, 2006, pp113.
  • Synthesis and vasoactive properties of methyl-mitroarachidonate. Blanco F, Trostchansky A, Castro D, López V, Migilaro ER, Cerecetto H, Rubbo H. Free Radicals in Montevideo, Montevideo, Uruguay, 2007, pp28.
  • Advances on the synthesis and biological characterization of nitrosothiol derivatives of alpha tocopherol: a pharmacological approach for atherogenesis. Gómez L, Silveira RG, Blanco F, Hernández P, Ferreira A, González M, Cerecetto H, López GV. Free Radicals in Montevideo, Montevideoo, Uruguay, 2007, pp111.
  •  Avances en la sintesis y evaluación biológica e tcoferol-miméticos liberadores de óxido nitrico. Gómez L, Silveira RG, Blanco F, Hernández P, González M, Rubbo H, Cerecetto H, López GV. XVI National Symposium of Organic Chemestry, Mar del Plata, Argentina, 2007.
  • Methyl-nitroarachidonate: Vasoactive properties and mechanism action. Blanco F, Ferreira AM, López GV, Trostchansky A, Migliaro ER, Rubbo H. XVII International Society of Heart Research Latin American Section, Buenos Aires, Argentina, 2009, pp248.
  • New synthetic NO-releasing vitamin E analogs for the potential treatment of atherosclerosis. LE Gómez, M González, H Cerecetto, F Blanco, H Rubbo, GV López. VI Meeting of Society of Free Radical Biology and Medicine South American Group, Santiago de Chile, Chile, 2009, pp114.
  • Inhibition of Nuclear Factor of Activated T-cells (NFAT) reduces diabetes-induced atherosclerosis. Anna V. Zetterqvist, Lisa M Berglund, Fabiana Blanco, Maria Wigren, Fong To, Jan Nilsson, Eva Bengtsson, Maria F Gomez. Experimental Biology, annual meeting, Washington, EEUU, 2011.

 

 

Last updated: February 7, 2012
Website contact: LUDC webteam

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